Polyurethanes ikoreshwa cyane mubikorwa byubuvuzi nkuruhu rwubukorikori, ibitanda byibitaro, imiyoboro ya dialyse, ibice byamahoro, catheters, hamwe nububiko.Ibinyabuzima bihuza, imiterere yubukanishi, nigiciro gito nibintu byingenzi biganisha ku gutsinda kwa polyurethanes mubuvuzi.

Iterambere ryatewe mubisanzwe risaba ibintu byinshi bigize ibinyabuzima, kuko umubiri ubyanga bike.Kubijyanye na polyurethanes, ibinyabuzima bishobora gutandukana kuva 30 kugeza 70%, ibyo bikaba bitanga intera yagutse kubisabwa muri utwo turere (2).Biyobase polyurethanes yiyongera ku isoko ryabo kandi biteganijwe ko mu 2022 izagera kuri miliyoni 42 z'amadolari, ni ukuvuga ijanisha rito ku isoko rusange rya polyurethane (munsi ya 0.1%).Nubwo bimeze bityo ariko, ni agace keza, kandi ubushakashatsi bwimbitse burakomeje kubijyanye no gukoresha ibikoresho byinshi bibogamye muri polyurethanes.Iterambere rirakenewe mumiterere ya biobased polyurethanes kugirango ihuze ibisabwa bihari, kugirango ishoramari ryiyongere.

Biobased kristaline polyurethane yashizwemo hakoreshejwe reaction ya PCL, HMDI, namazi yagize uruhare mukwagura urunigi (33).Ibizamini byo gutesha agaciro byakozwe kugira ngo bige ku gihagararo cya biopolyurethane mu mazi y’umubiri wigana, nka saline ya fosifeti.Impinduka

mubushuhe, ubukanishi, nibintu bifatika byasesenguwe kandi ugereranije nibyo bihwanye

polyurethane yabonetse binyuze mu gukoresha Ethylene glycol nk'iyagura urunigi aho gukoresha amazi.Ibisubizo byerekanye ko polyurethane yabonetse ikoresheje amazi nkuwagura urunigi yerekanaga ibintu byiza mugihe ugereranije na peteroli ihwanye nayo.Ibi ntibigabanuka cyane

ikiguzi cyibikorwa, ariko kandi itanga inzira yoroshye yo kubona ibikoresho byubuvuzi byongerewe agaciro bikwiranye na endoprostheses ()33).Ibyo byakurikiwe nubundi buryo bushingiye kuri iki gitekerezo, bwashushanyaga ureopa ya biopolyurethane ukoresheje amavuta y’ingufu zishingiye kuri polyol, PCL, HMDI, n’amazi nkuwagura urunigi (6).Kongera ubuso, sodium chlorine yakoreshejwe mugutezimbere ububobere bwa polymers yateguwe.Polimeri ya synthesize yakoreshejwe nka scafold kubera imiterere yabyo kugirango itume ingirabuzimafatizo zikura.Hamwe n'ibisubizo bisa ugereranije

kurugero rwabanjirije iki, polyurethane yagaragaye kumazi yumubiri wigana yerekanaga ituze ryinshi, itanga amahitamo meza kubikorwa bya scafold.Polyurethane ionomers ni irindi tsinda rishimishije rya polymers zikoreshwa mugukoresha imiti, nkibisubizo bya biocompatibilité no gukorana neza nibidukikije byumubiri.Iionomeri ya polyurethane irashobora gukoreshwa nkibigize umuyoboro wa pacemakers na hemodialysis (34, 35).

Iterambere rya sisitemu nziza yo gutanga ibiyobyabwenge nigice cyingenzi cyubushakashatsi cyibanda ku gushaka uburyo bwo guhangana na kanseri.Nanoparticle ya amphiphilic ya polyurethane ishingiye kuri L-lysine yateguwe kubisaba gutanga ibiyobyabwenge (36).Iyi nanocarrier

yapakiwe neza na doxorubicin, ikaba ari imiti ivura kanseri ya kanseri (Ishusho 16).Ibice bya hydrophobique ya polyurethane byakoranye nibiyobyabwenge, naho hydrophilique ikorana na selile.Sisitemu yaremye intangiriro-shell imiterere binyuze mu kwishyira hamwe

buryo kandi yashoboye gutanga neza ibiyobyabwenge binyuze munzira ebyiri.Ubwa mbere, ubushyuhe bwa nanoparticle bwagize uruhare runini mu kurekura imiti ku bushyuhe bwa kanseri ya kanseri (~ 41-43 ° C), ni igisubizo kidasanzwe.Icya kabiri, ibice bya alifatique ya polyurethane yarababaye

enzymatique biodegradation ikorwa na lysosomes, ituma doxorubicine irekurwa imbere muri selile ya kanseri;iki ni igisubizo kidasanzwe.Kurenga 90% by'uturemangingo twa kanseri y'ibere hapfuye, mu gihe cytotoxicitike yagumishijwe ku ngirabuzimafatizo nziza.

Igicapo 16. Muri rusange gahunda yo gutanga ibiyobyabwenge bishingiye kuri amphiphilic polyurethane nanoparticle

kwibasira kanseri. Yabyaye uruhushya rutangwa(36).Uburenganzira bwa 2019 Imiti y'Abanyamerika

Sosiyete.

Itangazo: Ingingo yavuzwe muriIntangiriro kuri Chimie ya PolyurethaneFelipe M. de Souza, 1 Pawan K. Kahol, 2 na Ram K.Gupta *, 1.Gusa kubijyanye no gutumanaho no kwiga, ntugakore izindi ntego zubucuruzi, ntabwo uhagarariye ibitekerezo nibitekerezo byikigo, niba ukeneye gusubiramo, nyamuneka hamagara umwanditsi wambere, niba hari ihohoterwa, nyamuneka twandikire ako kanya kugirango dusibe gutunganya.